Table of Contents
1 Table of Contents 2
1.1 List of Tables 3
1.2 List of Figures 4
2 Executive Summary 5
2.1 Related Reports 12
3 Epidemiology 13
3.1 Disease Background 13
3.2 Risk Factors and Comorbidities 14
3.3 Global Trends 15
3.3.1 Diagnosed Incidence and Diagnosed Prevalence 16
3.4 Forecast Methodology 18
3.4.1 Sources Used 18
3.4.2 Forecast Assumptions and Methods 25
3.4.3 Sources Not Used 34
3.5 Epidemiological Forecast for CF (2015-2025) 35
3.5.1 Diagnosed Incident Cases, Based on Registry Data 35
3.5.2 Diagnosed Prevalent Cases, Based on Registry Data 38
3.5.3 CF Mortality, Based on Registry Data 46
3.5.4 Diagnosed Incident Cases, Adjusted for Underestimation 49
3.5.5 Diagnosed Prevalent Cases, Adjusted for Underestimation 52
3.5.6 CF Mortality, Adjusted for Underestimation 59
3.6 Discussion 62
3.6.1 Epidemiological Forecast Insight 62
3.6.2 Limitations of the Analysis 63
3.6.3 Strengths of the Analysis 64
4 Appendix 65
4.1 Bibliography 65
4.2 Physicians and Specialists Included in this Study 67
4.3 High-Prescribing Physician Survey 69
4.4 About the Authors 69
4.4.1 Epidemiologist 69
4.4.2 Reviewers 70
4.4.3 Global Director of Therapy Analysis and Epidemiology 71
4.4.4 Global Head of Healthcare 71
4.5 About GlobalData 72
4.6 About EpiCast 72
4.7 Contact Us 73
4.8 Disclaimer 73
List of Tables
Table 1: Risk Factors and Comorbidities of CF 15
Table 2: 7MM, Sources Used to Forecast the Diagnosed Incident Cases of CF (Based on Registry Data) 19
Table 3: 7MM, Sources Used to Forecast the Diagnosed Prevalent Cases of CF (Based on Registry Data) 20
Table 4: 7MM, Sources Used for Segmentation of Diagnosed Prevalent Cases of CF by Specific Mutations (Based on Registry Data) 21
Table 5: 7MM, Sources Used to Forecast the Proportion of Diagnosed Prevalent Cases of CF by Chronic MRSA Infection (Based on Registry Data) 23
Table 6: 7MM, Sources Used to Forecast CF Deaths (Based on Registry Data) 24
Table 7: 7MM, Proportion of CF Cases Reported to Respective CF Registries (Primary Research) 24
Table 8: 7MM, Sources Not Used in the Epidemiological Analysis of CF 35
Table 9: 7MM, Diagnosed Incident Cases of CF, All Ages, Both Sexes, N, Selected Years 2015-2025 (Based on Registry Data) 36
Table 10: 7MM, Sex-Specific Diagnosed Incident Cases of CF, All Ages, N (Row %), 2015 (Based on Registry Data) 37
Table 11: 7MM, Diagnosed Prevalent Cases of CF, All Ages, Both Sexes, N, Selected Years 2015-2025 (Based on Registry Data) 39
Table 12: 7MM, Age-Specific Diagnosed Prevalent Cases of CF, Both Sexes, N (Row %), 2015 (Based on Registry Data) 40
Table 13: 7MM, Sex-Specific Diagnosed Prevalent Cases of CF, All Ages, N (Row %), 2015 (Based on Registry Data) 42
Table 14: 7MM, Diagnosed Prevalent Cases of CF with Chronic MRSA Infection, All Ages, Both Sexes, N, Selected Years 2015-2025 (Based on Registry Data) 46
Table 15: 7MM, CF Deaths, All Ages, Both Sexes, N, Selected Years 2015-2025 (Based on Registry Data) 47
Table 16: 7MM, Sex-Specific CF Deaths, All Ages, N (Row %), 2015 (Based on Registry Data) 48
Table 17: 7MM, Diagnosed Incident Cases of CF, All Ages, Both Sexes, N, Selected Years 2015-2025 (Adjusted for Underestimation) 50
Table 18: 7MM, Sex-Specific Diagnosed Incident Cases of CF, All Ages, N (Row %), 2015 (Adjusted for Underestimation) 51
Table 19: 7MM, Diagnosed Prevalent Cases of CF, All Ages, Both Sexes, N, Selected Years 2015-2025 (Adjusted for Underestimation) 53
Table 20: 7MM, Age-Specific Diagnosed Prevalent Cases of CF, Both Sexes, N (Row %), 2015 (Adjusted for Underestimation) 54
Table 21: 7MM, Sex-Specific Diagnosed Prevalent Cases of CF, All Ages, N (Row %), 2015 (Adjusted for Underestimation) 56
Table 22: 7MM, Diagnosed Prevalent Cases of CF with Chronic MRSA Infection, All Ages, Both Sexes, N, Selected Years 2015-2025 (Adjusted for Underestimation) 59
Table 23: 7MM, CF Deaths, All Ages, Both Sexes, N, Selected Years 2015-2025 (Adjusted for Underestimation) 60
Table 24: 7MM, Sex-Specific CF Deaths, All Ages, N (Row %), 2015 (Adjusted for Underestimation) 61
Table 25: High-Prescribing Physicians (Non-KOLs), Surveyed by Country, 2016 69
List of Figures
Figure 1: 7MM, Diagnosed Incident Cases of CF, All Ages, Both Sexes, N, 2015 and 2025 (Forecast Based on Registry Data) 6
Figure 2: 7MM, Diagnosed Prevalent Cases of CF, All Ages, Both Sexes, N, 2015 and 2025 (Forecast Based on Registry Data) 7
Figure 3: 7MM, CF Deaths, All Ages, Both Sexes, N, 2015 and 2025 (Forecast Based on Registry Data) 8
Figure 4: 7MM, Diagnosed Incident Cases of CF, All Ages, Both Sexes, N, 2015 and 2025 (Forecast Adjusted for Underestimation) 9
Figure 5: 7MM, Diagnosed Prevalent Cases of CF, All Ages, Both Sexes, N, 2015 and 2025 (Forecast Adjusted for Underestimation) 10
Figure 6: 7MM, CF Deaths, All Ages, Both Sexes, N, 2015 and 2025 (Forecast Adjusted for Underestimation) 11
Figure 7: 7MM, Diagnosed Incident Cases of CF, All Ages, Both Sexes, N, 2015-2025 (Based on Registry Data) 36
Figure 8: 7MM, Sex-Specific Diagnosed Incident Cases of CF, All Ages, N, 2015 (Based on Registry Data) 38
Figure 9: 7MM, Diagnosed Prevalent Cases of CF, All Ages, Both Sexes, N, Selected Years 2015-2025 (Based on Registry Data) 39
Figure 10: 7MM, Age-Specific Diagnosed Prevalent Cases of CF, Both Sexes, N, 2015 (Based on Registry Data) 41
Figure 11: 7MM, Sex-Specific Diagnosed Prevalent Cases of CF, All Ages, N, 2015 (Based on Registry Data) 43
Figure 12: 7MM, Age-Standardized Diagnosed Prevalence of CF, All Ages, N, 2015 (Based on Registry Data) 44
Figure 13: 7MM, Diagnosed Prevalent Cases of CF with Specific Mutations, Both Sexes, All Ages, N, 2015 (Based on Registry Data) 45
Figure 14: 7MM, Diagnosed Prevalent Cases of CF with Chronic MRSA Infection, Both Sexes, All Ages, N, 2015 (Based on Registry Data) 46
Figure 15: 7MM, CF Deaths, All Ages, Both Sexes, N, Selected Years 2015-2025 (Based on Registry Data) 47
Figure 16: 7MM, Sex-Specific CF Deaths, All Ages, N, 2015 (Based on Registry Data) 49
Figure 17: 7MM, Diagnosed Incident Cases of CF, All Ages, Both Sexes, N, 2015-2025 (Adjusted for Underestimation) 50
Figure 18: 7MM, Sex-Specific Diagnosed Incident Cases of CF, All Ages, N, 2015 (Adjusted for Underestimation) 52
Figure 19: 7MM, Diagnosed Prevalent Cases of CF, All Ages, Both Sexes, N, Selected Years 2015-2025 (Adjusted for Underestimation) 53
Figure 20: 7MM, Age-Specific Diagnosed Prevalent Cases of CF, Both Sexes, N, 2015 (Adjusted for Underestimation) 55
Figure 21: 7MM, Sex-Specific Diagnosed Prevalent Cases of CF, All Ages, N, 2015 (Adjusted for Underestimation) 57
Figure 22: 7MM, Diagnosed Prevalent Cases of CF with Specific Mutations, Both Sexes, All Ages, N, 2015 (Adjusted for Underestimation) 58
Figure 23: 7MM, Diagnosed Prevalent Cases of CF with Chronic MRSA Infection, Both Sexes, All Ages, N, 2015 (Adjusted for Underestimation) 59
Figure 24: 7MM, CF Deaths, All Ages, Both Sexes, N, Selected Years 2015-2025 (Adjusted for Underestimation) 60
Figure 25: 7MM, Sex-Specific CF Deaths, All Ages, N, 2015 (Adjusted for Underestimation) 62
