Vaccines for Emerging Infectious Diseases: Funding, R&D, and Global Partnership Strategies

Table of Contents
1. Preface
1.1 Table of Contents 2
1.2 Abbreviations 4
1.3 Related Reports 6
1.4 Upcoming Related Reports 7
2. Executive Summary 8
2.1 Key Findings 9
2.2 KOL Insights on Vaccines for Emerging Infectious Diseases 10
3. Overview of Emerging Infectious Diseases 11
3.1 Defining Emerging Infectious Diseases (EIDs) 13
3.2 Drivers of Emerging Infections & Routes of Transmission 15
3.3 Key EIDs 21
3.4 Ebola Virus Disease 22
3.5 Zika Virus Disease 25
3.6 Middle East Respiratory Syndrome (MERS) and Other EIDs 28
4. Clinical Trial Design 32
4.1 Clinical Trial Design Challenges 34
4.2 Randomization Units 35
4.3 Selection of Clinical Trial Population and Comparator 37
4.4 Additional Strategies for Vaccine Approvals 43
4.5 Unmet Needs in Clinical Trial Design 49
5. Vaccine Platform Technologies 50
5.1 Overview of Vaccine Platform Technologies 52
5.2 Vaccine Platforms By Stage of Development 55
5.3 Live-attenuated Vaccines 56
5.4 Viral Vector-Based Vaccines 57
5.5 DNA Vaccines 58
5.6 Whole-Inactivated Vaccines, Subunit Vaccines, and VLPs 60
6. Funding and Market Incentives 62
6.1 Funding Sources for Vaccines for EIDs 64
6.2 Push and Pull Incentives 65
6.3 Challenges for Funding of Vaccine Development 67
6.4 Lessons from the Ebola and Zika Outbreaks 70
7. Global Collaborations for Vaccine Development 73
7.1 Global Vaccine Development Fund and Priority Diseases 75
7.2 Coalition for Epidemic Preparedness Innovations (CEPI) 78
7.3 Vaccine Preparedness 82
7.4 Global Virome Project (GVP) and Other Public-Private Partnerships 84
8. Pipeline Vaccines for Key Emerging Infectious Diseases 87
8.1 Clinical Development of Vaccines for EIDs 89
8.2 Ebola Vaccine Pipeline 90
8.3 Zika Vaccine Pipeline 94
8.4 MERS-CoV Vaccine Pipeline 98
9. Surveillance and Healthcare Infrastructures 101
9.1 Disease Surveillance for EIDs 103
9.2 Logistical Challenges for Vaccine Delivery 107
9.3 Vaccine Preparedness 109
9.4 Unmet Needs in Basic Vaccine Research 111
10. Appendix 115
10.1 Sources 116
10.2 Methodology 119
10.3 Primary Research 120
10.4 About the Authors 121
10.5 About GlobalData 123